Rapamycin induces the fusion-type independent downregulation of the EWS/FLI-1 proteins and inhibits Ewing's sarcoma cell proliferation

Gene fusion with an ETS DNA-binding domain caused by chromosome translocation in human tumours

Olivier Delattre, Jessica Zucman‐Rossi, Béatrice Plougastel-Douglas et al. · Nature · 1992 · 1.9K citations

Life Sciences, Genetics, Molecular Genetics +17

Combinatorial generation of variable fusion proteins in the Ewing family of tumours.

Thomas Melot, Chantal Desmaze, Jacques Ghysdael et al. · The EMBO Journal · 1993 · 539 citations · Full text

Medicine, Molecular Biology, Oncology +15

p70s6k function is essential for G1 progression

Heidi A. Lane, Anne Fernandez, Ned Lamb et al. · Nature · 1993 · 345 citations

Life Sciences, Cell Biology, Molecular Biology +13

Repression of the gene encoding the TGF-β type II receptor is a major target of the EWS-FLI1 oncoprotein

Ki‐Baik Hahm, K W Cho, Cecile Lee et al. · Nature Genetics · 1999 · 345 citations

Medicine, Genetics, Molecular Biology +10

A role of the kinase mTOR in cellular transformation induced by the oncoproteins P3k and Akt

Masahiro Aoki, Erik Blazek, Peter K. Vogt · Proceedings of the National Academy of Sciences · 2000 · 293 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17