Concepedia

Replicative retroviral vectors for cancer gene therapy

Sounkary Solly, Stéphane Trajcevski, Charlotte Frisén, Georg W. Holzer, Elisabeth Nelson, Béatrice Clerc, Evelyn Abordo‐Adesida, María G. Castro, Pedro R. Löwenstein, David Klatzmann

Cancer Gene Therapy · 2002 · 81 citations · 50 references

DOI

Concepts

References

50

An Adenovirus Mutant That Replicates Selectively in p53- Deficient Human Tumor Cells

James R. Bischoff, David H. Kirn, Angelica Williams et al. · Science · 1996 · 1.8K citations

, , +14

Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection.

Mohammed Adam, A. Dusty Miller · Molecular and Cellular Biology · 1990 · 1.4K citations · Full text

, , +14

A controlled trial of intratumoral ONYX-015, a selectively-replicating adenovirus, in combination with cisplatin and 5-fluorouracil in patients with recurrent head and neck cancer

Fadlo R. Khuri, John Nemunaitis, Ian Ganly et al. · Nature Medicine · 2000 · 1.1K citations

, , +8

The "bystander effect": tumor regression when a fraction of the tumor mass is genetically modified.

Sara M. Freeman, Camille N. Abboud, Katharine A. Whartenby et al. · PubMed · 1993 · 1.1K citations

, , +10

Experimental Therapy of Human Glioma by Means of a Genetically Engineered Virus Mutant

Robert L. Martuza, Amy Malick, James M. Markert et al. · Science · 1991 · 1K citations

, , +14