Proapoptotic BAX and BAK: A Requisite Gateway to Mitochondrial Dysfunction and Death

Michael C. Wei, Wei‐Xing Zong, Emily H. Cheng, +7

Science

DNA damage activates ATM through intermolecular autophosphorylation and dimer dissociation

Christopher J. Bakkenist, Michael B. Kastan

Nature

ChromatinGenome InstabilityDna DamageChromatin RemodelingNatural Sciences +4

A specific inhibitor of phosphatidylinositol 3-kinase, 2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one (LY294002).

Chris J. Vlahos, William F. Matter, K. Y. Hui, +1

Journal of Biological Chemistry

Specific InhibitorMolecular PharmacologyMedicinal ChemistrySignaling PathwayReceptor Tyrosine Kinase +14

Two CD95 (APO-1/Fas) signaling pathways

Carsten Scaffidi

The EMBO Journal

Signal TransductionSignaling PathwayMolecular PathwayApoptosisSignaling Pathways +4

Activation of the ATM Kinase by Ionizing Radiation and Phosphorylation of p53

Christine E. Canman, Dae‐Sik Lim, Karlene A. Cimprich, +6

Science

Tumor BiologyUltraviolet RadiationSignal TransductionAtm KinaseReceptor Tyrosine Kinase +12

Enhanced Phosphorylation of p53 by ATM in Response to DNA Damage

Sharon Banin, Lilach Moyal, Sheau-Yann Shieh, +8

Science

Tolerance in T-cell-receptor transgenic mice involves deletion of nonmature CD4+8+ thymocytes

Paweł Kisielow, Horst Blüthmann, Uwe D. Staerz, +2

Nature

Lymphocyte DevelopmentImmunologyAutoimmunitySelf-toleranceT-cell-receptor Transgenic Mice +5

p53- and Drug-Induced Apoptotic Responses Mediated by BH3-Only Proteins Puma and Noxa

Andreas Villunger, Ewa M. Michalak, Leigh Coultas, +5

Science

Bid-induced Conformational Change of Bax Is Responsible for Mitochondrial Cytochrome c Release during Apoptosis

Solange Desagher, Astrid Osen‐Sand, Anthony C. Nichols, +6

The Journal of Cell Biology

MitophagyApoptosisImmunologyCell DeathMolecular Biology +17

DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts.

Aldo Di Leonardo, Steven P. Linke, Kristie Clarkin, +1

Genes & Development

Normal Human FibroblastsDna DamagePathologyCell DeathCell Cycle +18