Prediction of Human Metabolism of FK3453 by Aldehyde Oxidase Using Chimeric Mice Transplanted with Human or Rat Hepatocytes

Near Completely Humanized Liver in Mice Shows Human-Type Metabolic Responses to Drugs

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Medicine, Pharmacokinetics, Pharmacology +12

Aldehyde Oxidase: An Enzyme of Emerging Importance in Drug Discovery

David C. Pryde, Deepak Dalvie, Qiyue Hu et al. · Journal of Medicinal Chemistry · 2010 · 346 citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +10

In vitro oxidation of famciclovir and 6-deoxypenciclovir by aldehyde oxidase from human, guinea pig, rabbit, and rat liver.

Mohammad‐Reza Rashidi, John A. Smith, Stephen E. Clarke et al. · PubMed · 1997 · 157 citations

Life Sciences, Biochemistry, Pharmacology +11

Species-Specific Metabolism of SGX523 by Aldehyde Oxidase and the Toxicological Implications

Sharon Diamond, Jason Boer, Thomas Maduskuie et al. · Drug Metabolism and Disposition · 2010 · 138 citations

Medicine, Pharmacology, Toxicology +15

In Vitro-In Vivo Correlation for Intrinsic Clearance for Drugs Metabolized by Human Aldehyde Oxidase

Michael Zientek, Ying Jiang, Kuresh Youdim et al. · Drug Metabolism and Disposition · 2010 · 126 citations

Pharmacy, Pharmacokinetics, Pharmacology +15