Pyrin Activates the ASC Pyroptosome in Response to Engagement by Autoinflammatory PSTPIP1 Mutants

Mutation of a new gene encoding a putative pyrin-like protein causes familial cold autoinflammatory syndrome and Muckle–Wells syndrome

Hal M. Hoffman, James L. Mueller, David H. Broide et al. · Nature Genetics · 2001 · 1.6K citations · Full text

Mendelian Disorder, Disease Mechanism, Genetic Disorder +9

Ancient Missense Mutations in a New Member of the RoRet Gene Family Are Likely to Cause Familial Mediterranean Fever

The International FMF Consortium · Cell · 1997 · 1.5K citations · Full text

Mendelian Disorder, Reverse Genetics, Genetic Disorder +9

A candidate gene for familial Mediterranean fever

Nature Genetics · 1997 · 1.5K citations

Genetics, Pathogenesis, Genetic Epidemiology +4

The tripartite motif family identifies cell compartments

Alexandre Reymond · The EMBO Journal · 2001 · 1.4K citations · Full text

Cell Organelle, Natural Sciences, Molecular Biology +7

The pyroptosome: a supramolecular assembly of ASC dimers mediating inflammatory cell death via caspase-1 activation

Teresa Fernandes‐Alnemri, Jiang Wu, Je‐Wook Yu et al. · Cell Death and Differentiation · 2007 · 1K citations · Full text

Inflammation, Anti-inflammatory, Signal Transduction +11