Emad S. Alnemri

Cytochrome c and dATP-Dependent Formation of Apaf-1/Caspase-9 Complex Initiates an Apoptotic Protease Cascade

Peng Li, Deepak Nijhawan, I. Imawati Budihardjo et al. · Cell · 1997 · 7.3K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition)

Daniel J. Klionsky, Kotb Abdelmohsen, Akihisa Abe et al. · Autophagy · 2016 · 6K citations · Full text

Life Sciences, Cell Biology, Pathology +9

Cutting Edge: NF-κB Activating Pattern Recognition and Cytokine Receptors License NLRP3 Inflammasome Activation by Regulating NLRP3 Expression

Franz Bauernfeind, Gábor Horváth, Andrea Stutz et al. · The Journal of Immunology · 2009 · 2.9K citations · Full text

Life Sciences, Immunology, Molecular Biology +17

The ketone metabolite β-hydroxybutyrate blocks NLRP3 inflammasome–mediated inflammatory disease

Yun‐Hee Youm, Kim Nguyen, Ryan W. Grant et al. · Nature Medicine · 2015 · 2.1K citations · Full text

Life Sciences, Immunology, Pharmacology +14

Ordering the Cytochrome c–initiated Caspase Cascade: Hierarchical Activation of Caspases-2, -3, -6, -7, -8, and -10 in a Caspase-9–dependent Manner

Elizabeth A. Slee, Mary T. Harte, Ruth M. Kluck et al. · The Journal of Cell Biology · 1999 · 1.9K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16