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Novel triazines as potent and selective phosphodiesterase 10A inhibitors

Michael S. Malamas, Hans Stange, Rudolf Schindler, Hans‐Joachim Lankau, Christian Grunwald, Barbara Langen, Ute Egerland, Thorsten Hage, Yike Ni, James Erdei,

Bioorganic & Medicinal Chemistry Letters · 2012 · 26 citations · 15 references

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References

15

Cloning and Characterization of a Novel Human Phosphodiesterase That Hydrolyzes Both cAMP and cGMP (PDE10A)

Kotomi Fujishige, Jun Kotera, Hideo Michibata et al. · Journal of Biological Chemistry · 1999 · 407 citations · Full text

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Isolation and characterization of a dual-substrate phosphodiesterase gene family: PDE10A

Scott H. Soderling, Sharon J. Bayuga, Joseph A. Beavo · Proceedings of the National Academy of Sciences · 1999 · 381 citations

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Immunohistochemical localization of PDE10A in the rat brain

Thomas Seeger, Brenda L. Bartlett, Timothy Coskran et al. · Brain Research · 2003 · 340 citations

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A Glutamine Switch Mechanism for Nucleotide Selectivity by Phosphodiesterases

Kam Y. J. Zhang, G.L. Card, Yoshihisa Suzuki et al. · Molecular Cell · 2004 · 297 citations · Full text

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Phosphodiesterase 10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive, and Negative Symptoms of Schizophrenia

Steven M. Grauer, Virginia Pulito, Rachel L. Navarra et al. · Journal of Pharmacology and Experimental Therapeutics · 2009 · 266 citations

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