Phosphodiesterase 10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive, and Negative Symptoms of Schizophrenia

Steven M. Grauer, Virginia Pulito, Rachel L. Navarra, +15

Journal of Pharmacology and Experimental Therapeutics

Extracellular Matrix Components HAPLN1, Lumican, and Collagen I Cause Hyaluronic Acid-Dependent Folding of the Developing Human Neocortex

Katherine R. Long, Ben Newland, Marta Florio, +5

Neuron

MechanobiologyTissue EngineeringDevelopmental BiologyEngineeringMedicine +8

Neocortical Expansion Due to Increased Proliferation of Basal Progenitors Is Linked to Changes in Their Morphology

Nereo Kalebic, Carlotta Gilardi, Barbara K. Stepien, +11

Cell stem cell

Developmental BiologyBrain StructureBasal ProgenitorsNeuroanatomyCortical Remodeling +9

Human-specific ARHGAP11B induces hallmarks of neocortical expansion in developing ferret neocortex

Nereo Kalebic, Carlotta Gilardi, Mareike Albert, +5

eLife

Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors

Michael S. Malamas, Yike Ni, James Erdei, +20

Journal of Medicinal Chemistry

Medicinal ChemistryDrug TargetPharmaceutical ScienceBiochemistryMedicine +13

Comparison of SHR, WKY and Wistar rats in different behavioural animal models: effect of dopamine D1 and alpha2 agonists

Barbara Langen, Rita Dost

ADHD Attention Deficit and Hyperactivity Disorders

Behavioral SciencesBehavioral NeuroscienceMedicineBehavioural PharmacologyBehavioral Pharmacology +10

YAP Activity Is Necessary and Sufficient for Basal Progenitor Abundance and Proliferation in the Developing Neocortex

Miloš Kostić, Judith T.M.L. Paridaen, Katherine R. Long, +7

Cell Reports

Discovery of Imidazo[1,5-<i>a</i>]pyrido[3,2-<i>e</i>]pyrazines as a New Class of Phosphodiesterase 10A Inhibitiors

Norbert Höfgen, Hans Stange, Rudolf Schindler, +12

Journal of Medicinal Chemistry

Crystal StructureBioorganic ChemistryPharmacotherapyChemical BiologyPharmaceutical Chemistry +14

Characterization in Rats of the Anxiolytic Potential of ELB139 [1-(4-Chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a New Agonist at the Benzodiazepine Binding Site of the GABAA Receptor

Barbara Langen, Ute Egerland, Katrin Bernöster, +3

Journal of Pharmacology and Experimental Therapeutics

Acute effect of ethanol on anxiety and 5-HT in the prefrontal cortex of rats

Barbara Langen, Silke Dietze, Heidrun Fink

Alcohol

Substance AbusePsychoactive DrugPsychiatryBehavioral NeuroscienceAddiction +12