Phosphodiesterase 10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive, and Negative Symptoms of Schizophrenia

Steven M. Grauer, Virginia Pulito, Rachel L. Navarra, +15

Journal of Pharmacology and Experimental Therapeutics

Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors

Michael S. Malamas, Yike Ni, James Erdei, +20

Journal of Medicinal Chemistry

Medicinal ChemistryDrug TargetPharmaceutical ScienceBiochemistryMedicine +13

New GABA-modulating 1,2,4-oxadiazole derivatives and their anticonvulsant activity

Hans‐Joachim Lankau, Klaus Unverferth, Christian Grunwald, +6

European Journal of Medicinal Chemistry

DerivativesMedicineMechanism Of ActionPharmacological AgentNeuropharmacology +5

Discovery of Imidazo[1,5-<i>a</i>]pyrido[3,2-<i>e</i>]pyrazines as a New Class of Phosphodiesterase 10A Inhibitiors

Norbert Höfgen, Hans Stange, Rudolf Schindler, +12

Journal of Medicinal Chemistry

Crystal StructureBioorganic ChemistryPharmacotherapyChemical BiologyPharmaceutical Chemistry +14

Anti-Inflammatory Potential of the Selective Phosphodiesterase 4 Inhibitor N-(3,5-Dichloro-pyrid-4-yl)-[1-(4-fluorobenzyl)-5-hydroxy-indole-3-yl]-glyoxylic Acid Amide (AWD 12-281), in Human Cell Preparations

Regina Draheim, Ute Egerland, Chris Rundfeldt

Journal of Pharmacology and Experimental Therapeutics

Synthesis, Pharmacology, and Structure−Activity Relationships of Novel Imidazolones and Pyrrolones as Modulators of GABA_AReceptors

Christian Grunwald, Chris Rundfeldt, Hans‐Joachim Lankau, +6

Journal of Medicinal Chemistry

Discovery of triazines as potent, selective and orally active PDE4 inhibitors

Rainer Gewald, Christian Grunwald, Ute Egerland

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryMedicineNatural SciencesPharmacological Agent +8

Characterization in Rats of the Anxiolytic Potential of ELB139 [1-(4-Chlorophenyl)-4-piperidin-1-yl-1,5-dihydro-imidazol-2-on], a New Agonist at the Benzodiazepine Binding Site of the GABAA Receptor

Barbara Langen, Ute Egerland, Katrin Bernöster, +3

Journal of Pharmacology and Experimental Therapeutics

Effect of PDE10A inhibitors on MK-801-induced immobility in the forced swim test

Barbara Langen, Rita Dost, Ute Egerland, +2

Psychopharmacology

PharmacologyMk-801-induced ImmobilityMedicinePde10a InhibitorsForced Swim Test +1

Novel triazines as potent and selective phosphodiesterase 10A inhibitors

Michael S. Malamas, Hans Stange, Rudolf Schindler, +20

Bioorganic & Medicinal Chemistry Letters

Inhibitory ActivityMedicinal ChemistryMedicinePharmacotherapyDrug Development +4