Generic expansion of the substrate spectrum of a DNA polymerase by directed evolution

Effects of primer-template mismatches on the polymerase chain reaction: Human immunodeficiency virus type 1 model studies

Shirley Kwok, D.E. Kellogg, Nancy McKinney et al. · Nucleic Acids Research · 1990 · 1K citations · Full text

PCR amplification of up to 35-kb DNA with high fidelity and high yield from lambda bacteriophage templates.

Wayne M. Barnes · Proceedings of the National Academy of Sciences · 1994 · 1K citations · Full text

Genetics, Bacteriophage, Dna Analysis +20

Molecular evolution by staggered extension process (StEP) in vitro recombination

Huimin Zhao, Lori Giver, Zhixin Shao et al. · Nature Biotechnology · 1998 · 755 citations

Molecular Biotechnology, Engineering, Directed Evolution +10

Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet

Joseph A. Piccirilli, Steven A. Benner, Tilman Krauch et al. · Nature · 1990 · 641 citations

Enzymatic Incorporation, Nucleic Acid Chemistry, Dna +13

Crystal Structure of a Y-Family DNA Polymerase in Action

Hong Ling, François Boudsocq, Roger Woodgate et al. · Cell · 2001 · 604 citations · Full text

Crystal Structure, Natural Sciences, Protein X-ray Crystallography +3