Enzymatic incorporation of a new base pair into DNA and RNA extends the genetic alphabet

Origin of life: The RNA world

Walter Gilbert · Nature · 1986 · 2.6K citations · Full text

Biology, Natural Sciences, Genetics +9

Oligoribonucleotide synthesis using T7 RNA polymerase and synthetic DNA templates

John F. Milligan, Duncan R. Groebe, Gary W. Witherell et al. · Nucleic Acids Research · 1987 · 2.2K citations · Full text

Rapid and sensitive colorimetric method for visualizing biotin-labeled DNA probes hybridized to DNA or RNA immobilized on nitrocellulose: Bio-blots.

Jeffry J. Leary, David J. Brigati, David C. Ward · Proceedings of the National Academy of Sciences · 1983 · 1.1K citations · Full text

Engineering, Biomolecular Tool, Biotinylated Analogs +20

A General Method for Site-specific Incorporation of Unnatural Amino Acids into Proteins

Christopher J. Noren, Spencer J. Anthony‐Cahill, Michael Griffith et al. · Science · 1989 · 1K citations

A small catalytic oligoribonucleotide

Olke C. Uhlenbeck · Nature · 1987 · 933 citations

Natural Sciences, Oligonucleotide, Dna Replication +2