Nitric oxide activates Nrf2 through S-nitrosylation of Keap1 in PC12 cells

Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants

Albena T. Dinkova‐Kostova, W. David Holtzclaw, Robert N. Cole et al. · Proceedings of the National Academy of Sciences · 2002 · 1.9K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Keap1-dependent Proteasomal Degradation of Transcription Factor Nrf2 Contributes to the Negative Regulation of Antioxidant Response Element-driven Gene Expression

Michael McMahon, Ken Itoh, Masayuki Yamamoto et al. · Journal of Biological Chemistry · 2003 · 1.1K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +12

Nrf1 and Nrf2 positively and c-Fos and Fra1 negatively regulate the human antioxidant response element-mediated expression of NAD(P)H:quinone oxidoreductase ₁  gene

Venugopal Radjendirane, Anil K. Jaiswal · Proceedings of the National Academy of Sciences · 1996 · 1K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Phosphorylation of Nrf2 at Ser-40 by Protein Kinase C Regulates Antioxidant Response Element-mediated Transcription

H.-C. Huang, Truyen Nguyen, Cecil B. Pickett · Journal of Biological Chemistry · 2002 · 1K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +16

Oxidative and Electrophilic Stresses Activate Nrf2 through Inhibition of Ubiquitination Activity of Keap1

Akira Kobayashi, Moon-Il Kang, Yoriko Watai et al. · Molecular and Cellular Biology · 2005 · 930 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +17