Chaperonin-mediated de novo generation of prion protein aggregates

Conversion of alpha-helices into beta-sheets features in the formation of the scrapie prion proteins.

K M Pan, M. A. Baldwin, Jack Nguyen et al. · Proceedings of the National Academy of Sciences · 1993 · 2.3K citations

Life Sciences, Biochemistry, Molecular Biology +17

Hsp104, Hsp70, and Hsp40

John R. Glover, Susan Lindquist · Cell · 1998 · 1.4K citations · Full text

Life Sciences, Molecular Biology, Molecular Genetics +3

Structural Analysis of Substrate Binding by the Molecular Chaperone DnaK

Xiaotian Zhu, Xun Zhao, William F. Burkholder et al. · Science · 1996 · 1.3K citations

Life Sciences, Biochemistry, Molecular Biology +17

Prion protein (PrP) with amino‐proximal deletions restoring susceptibility of PrP knockout mice to scrapie.

Michael B. Fischer, Thomas Rülicke, Alex J. Raeber et al. · The EMBO Journal · 1996 · 876 citations · Full text

Veterinary Medicine, Molecular Biology, Molecular Genetics +16

Chaperonin-mediated protein folding at the surface of groEL through a 'molten globule'-like intermediate

Jörg Martin, Thomas Langer, Raina Boteva et al. · Nature · 1991 · 860 citations

Life Sciences, Biochemistry, Molecular Biology +14