Concepedia

Synthesis of 5-substituted-1H-pyrazolo[4,3-d]pyrimidin-7(6H)-one analogs and their biological evaluation as anticancer agents: mTOR inhibitors

G. Lakshma Reddy, Santosh Kumar Guru, M. Srinivas, Anup S. Pathania, Priya Mahajan, Amit Nargotra, Shashi Bhushan, Ram A. Vishwakarma, Sanghapal D. Sawant

European Journal of Medicinal Chemistry · 2014 · 42 citations · 21 references

DOI

Concepts

References

21

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

Morris E. Feldman, Beth Apsel, Aino Uotila et al. · PLoS Biology · 2009 · 1.1K citations · Full text

, , +17

mTOR kinase structure, mechanism and regulation

Haijuan Yang, Derek G. Rudge, Joseph D. Koos et al. · Nature · 2013 · 1.1K citations

, , +12

Dichlorophenyl phosphoramidates as substrates for avian and mammalian liver phosphotriesterases: activity levels, calcium dependence and stereospecificity

Antonio Monroy‐Noyola, Miguel Á. Sogorb, N. Dı́az-Alejo et al. · Chemico-Biological Interactions · 1999 · 535 citations

, , +3

Effective and selective targeting of leukemia cells using a TORC1/2 kinase inhibitor

Matthew R. Janes, Jose J. Limon, Lomon So et al. · Nature Medicine · 2010 · 338 citations · Full text

, , +14

Rapamycin and other longevity‐promoting compounds enhance the generation of mouse induced pluripotent stem cells

Taotao Chen, Shen Li, Jie Yu et al. · Aging Cell · 2011 · 204 citations

, , +17