Activation of sirtuin 1 attenuates cerebral ventricular streptozotocin-induced tau hyperphosphorylation and cognitive injuries in rat hippocampi

Nutrient control of glucose homeostasis through a complex of PGC-1α and SIRT1

Joseph T. Rodgers, Carles Lerín, Wilhelm Haas et al. · Nature · 2005 · 3.1K citations

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Small molecule activators of SIRT1 as therapeutics for the treatment of type 2 diabetes

Jill C. Milne, Philip Lambert, Simon Schenk et al. · Nature · 2007 · 1.7K citations · Full text

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Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer's disease – is this type 3 diabetes?

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Diabetes Mellitus and Risk of Alzheimer Disease and Decline in Cognitive Function

Zoe Arvanitakis, R. J. Wilson, Julia L. Bienias et al. · Archives of Neurology · 2004 · 1.3K citations

Medicine, Geriatric Medicine, Neurology +17

SIRT1 deacetylase protects against neurodegeneration in models for Alzheimer's disease and amyotrophic lateral sclerosis

Do‐Hoon Kim, Minh Dang Nguyen, Matthew M. Dobbin et al. · The EMBO Journal · 2007 · 1.1K citations · Full text

Life Sciences, Molecular Biology, Neuroscience +14