Concepedia

The identification of potent, selective and CNS penetrant furan-based inhibitors of B-Raf kinase

Andrew K. Takle, Mark J. Bamford, Susannah Davies, Robert P. Davis, David K. Dean, Alessandra Gaiba, Elaine Irving, Frank D. King, A. Naylor, Christopher A. Parr,

Bioorganic & Medicinal Chemistry Letters · 2008 · 26 citations · 11 references

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11

Mutations of the BRAF gene in human cancer

Helen Davies, Graham R. Bignell, Charles Cox et al. · Nature · 2002 · 10.7K citations

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Specificity and mechanism of action of some commonly used protein kinase inhibitors

Stephen Davies, Helen Reddy, Matilde Caivano et al. · Biochemical Journal · 2000 · 4.1K citations · Full text

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Fast Calculation of Molecular Polar Surface Area as a Sum of Fragment-Based Contributions and Its Application to the Prediction of Drug Transport Properties

Peter Ertl, Bernhard Rohde, Paul M. Selzer · Journal of Medicinal Chemistry · 2000 · 3K citations

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Mitogen-Activated Protein (MAP) Kinase Pathways: Regulation and Physiological Functions

Endocrine Reviews · 2001 · 1.1K citations

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Polar Molecular Surface as a Dominating Determinant for Oral Absorption and Brain Penetration of Drugs

J. Kelder, Peter D. J. Grootenhuis, Denis M. Bayada et al. · Pharmaceutical Research · 1999 · 799 citations

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