Protein phosphorylation regulated by cyclic nucleotide-dependent protein kinases in cell extracts and in intact human lymphocytes

Transmembrane signalling by the T cell antigen receptor. Perturbation of the T3-antigen receptor complex generates inositol phosphates and releases calcium ions from intracellular stores.

John B. Imboden, John D. Stobo · The Journal of Experimental Medicine · 1985 · 732 citations

T-regulatory Cell, Immunology, Ca2+ Ionophore +16

T Cell Antigen Receptor-Mediated Activation of Phospholipase C Requires Tyrosine Phosphorylation

Tomas Mustelin, K. Mark Coggeshall, Noah Isakov et al. · Science · 1990 · 462 citations

Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation.

C H June, Mary C. Fletcher, J A Ledbetter et al. · The Journal of Immunology · 1990 · 427 citations

Phenotype of the accessory cell necessary for mitogen-stimulated T and B cell responses in human peripheral blood: delineation by its sensitivity to the lysosomotropic agent, L-leucine methyl ester.

Dwain L. Thiele, Masahiro Kurosaka, P E Lipsky · The Journal of Immunology · 1983 · 353 citations

Apoptosis, Immunology, Blood Cell +16

Prostaglandin E2 acts at two distinct pathways of T lymphocyte activation: inhibition of interleukin 2 production and down-regulation of transferrin receptor expression.

Karl Welte, R Mertelsmann, Bo Dupont · The Journal of Immunology · 1985 · 307 citations · Full text

Il 2, Immunology, Immune Regulation +19