CD28 costimulation can promote T cell survival by enhancing the expression of Bcl-xL

Lawrence Boise, Andy J. Minn, Patricia J. Noel, +4

Immunity

T Cell SurvivalCell TherapyAdaptive Immune SystemImmunologyCd28 Costimulation +6

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

C H June, Mary C. Fletcher, J A Ledbetter, +4

Proceedings of the National Academy of Sciences

ImmunologyImmunologic MechanismAntigen ProcessingImmunotherapyCellular Physiology +15

Increases in tyrosine phosphorylation are detectable before phospholipase C activation after T cell receptor stimulation.

C H June, Mary C. Fletcher, J A Ledbetter, +1

The Journal of Immunology

Heterogeneity among T cells in intracellular free calcium responses after mitogen stimulation with PHA or anti-CD3. Simultaneous use of indo-1 and immunofluorescence with flow cytometry.

Peter S. Rabinovitch, C H June, Angelika Grossmann, +1

The Journal of Immunology

Immunocytochemical TechniqueCd4+ CellsLaboratory ImmunologyImmunologyImmunophenotyping +18

Decreased dependence of myelin basic protein-reactive T cells on CD28-mediated costimulation in multiple sclerosis patients. A marker of activated/memory T cells.

Amy E. Lovett‐Racke, John L. Trotter, Jörg Lauber, +3

Journal of Clinical Investigation

T-regulatory CellImmunologyCd4 T Cell ResponsesT CellsImmunotherapy +15

Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes.

J A Ledbetter, C H June, Laura S. Grosmaire, +1

Proceedings of the National Academy of Sciences

T-regulatory CellImmunologyImmune RegulationImmunodominanceImmunologic Mechanism +17

IgE secretion by Epstein-Barr virus-infected purified human B lymphocytes is stimulated by interleukin 4 and suppressed by interferon gamma.

George Thyphronitis, George C. Tsokos, C H June, +2

Proceedings of the National Academy of Sciences

InflammationInterferon GammaAutoimmune DiseaseEpstein-barr VirusHumoral Response +13

AU RNA-binding factors differ in their binding specificities and affinities.

Paul R. Bohjanen, B Petryniak, C H June, +2

Journal of Biological Chemistry

EngineeringT-regulatory CellImmunologyMolecular BiologyImmunologic Mechanism +20

Growth factors can enhance lymphocyte survival without committing the cell to undergo cell division.

Lawrence Boise, Andy J. Minn, C H June, +2

Proceedings of the National Academy of Sciences

Lymphocyte DevelopmentT-regulatory CellImmune RegulationImmunologyImmunologic Mechanism +18

An HIV-1-infected T cell clone defective in IL-2 production and Ca2+ mobilization after CD3 stimulation

Víctor Pérez, Thomas Rowe, J. Shawn Justement, +3

The Journal of Immunology