Insertional mutagenesis of the vaccinia virus gene encoding a type I DNA topoisomerase: Evidence that the gene is essential for virus growth

Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.

Y H Hsiang, Robert Hertzberg, Sidney M. Hecht et al. · Journal of Biological Chemistry · 1985 · 2.4K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +15

Isolation of type I and II DNA topoisomerase mutants from fission yeast: single and double mutants show different phenotypes in cell growth and chromatin organization.

Tadashi Uemura, Mitsuhiro Yanagida · The EMBO Journal · 1984 · 449 citations · Full text

Life Sciences, Cell Biology, Genetics +14

Escherichia coli gpt gene provides dominant selection for vaccinia virus open reading frame expression vectors

Falko G. Falkner, Bernard Moss · Journal of Virology · 1988 · 316 citations · Full text

Life Sciences, Biotechnology, Molecular Biology +13

Conserved TAAATG sequence at the transcriptional and translational initiation sites of vaccinia virus late genes deduced by structural and functional analysis of the HindIII H genome fragment

Johannes Rösel, Patricia L. Earl, Jerry P. Weir et al. · Journal of Virology · 1986 · 264 citations · Full text

Life Sciences, Genetics, Molecular Biology +15

Characterization of vaccinia virus DNA topoisomerase I expressed in Escherichia coli.

Stewart Shuman, Michael Golder, Bernard Moss · Journal of Biological Chemistry · 1988 · 141 citations · Full text

Life Sciences, Microbiology, Molecular Biology +10