Concepedia

Topoisomerase Function In Replication

Topoisomerase Function in Replication is a molecular biological mechanism that resolves topological strain in DNA during eukaryotic replication by transiently cleaving and rejoining phosphodiester bonds to prevent overwinding and ensure replication fork progression.

477

Publications

34.8K

Citations

1.6K

Authors

479

Institutions

Publications per year

2017–2026

63

Parents

Publications

477

DNA gyrase, topoisomerase IV, and the 4-quinolones.

Karl Drlica, Xilin Zhao · Microbiology and Molecular Biology Reviews · 1997 · 891 citations

, , +11

Crystal Structures of Human Topoisomerase I in Covalent and Noncovalent Complexes with DNA

Matthew R. Redinbo, Lance Stewart, Peter Kühn et al. · Science · 1998 · 878 citations

, , +13

DNA topoisomerase II mutant of Saccharomyces cerevisiae: topoisomerase II is required for segregation of daughter molecules at the termination of DNA replication.

Stephen DiNardo, K Voelkel, Rolf Sternglanz · Proceedings of the National Academy of Sciences · 1984 · 685 citations · Full text

, , +14

New topoisomerase essential for chromosome segregation in E. coli

Junichi Kato, Yukinobu Nishimura, Ryu Imamura et al. · Cell · 1990 · 562 citations

, , +14

Topoisomerase I suppresses genomic instability by preventing interference between replication and transcription

Sandie Tuduri, Laure Crabbé, Chiara Conti et al. · Nature Cell Biology · 2009 · 532 citations · Full text

, , +12

1–5 of 477

Authors

1.6K

  1. KJ
    Kenneth J. Marians

    Memorial Sloan Kettering Cancer Center, United States

    16 publications · 1.5K citations

    16

    h-index

  2. P
    Yves Pommier

    National Cancer Institute, United States

    14 publications · 1.6K citations

    14

    h-index

  3. HH
    Hiroshi Hiasa

    University of Minnesota Medical Center, United States

    12 publications · 607 citations

    12

    h-index

  4. NO
    Neil Osheroff

    Vanderbilt University, United States

    13 publications · 797 citations

    12

    h-index

  5. JC
    James C. Wang

    Harvard University, United States

    12 publications · 1.6K citations

    12

    h-index

1–5 of 1.6K

Institutions

479

  1. Harvard University

    Cambridge, United States

    18 h-index

    36 publications

    4.2K citations

  2. National Institutes of Health

    Bethesda, United States

    17 h-index

    67 publications

    6.7K citations

  3. Memorial Sloan Kettering Cancer Center

    New York, United States

    17 h-index

    39 publications

    3.8K citations

  4. Vanderbilt University

    Nashville, United States

    15 h-index

    70 publications

    3.2K citations

  5. Johns Hopkins University

    Baltimore, United States

    15 h-index

    42 publications

    3.5K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    15 h-index

    80 publications

    8.1K citations

  7. University of California, Berkeley

    Berkeley, United States

    13 h-index

    43 publications

    8K citations

  8. National Cancer Institute

    Bethesda, United States

    12 h-index

    44 publications

    4.6K citations

1–8 of 479

Venues

  1. Journal of Biological Chemistry

    JBC · 51 publications · 4.2K citations

    35

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 36 publications · 3.9K citations

    31

    h-index

  3. Nucleic Acids Research

    52 publications · 2.3K citations

    30

    h-index

  4. Molecular and Cellular Biology

    MCB · 17 publications · 1.5K citations

    17

    h-index

  5. Journal of Molecular Biology

    JMB · 18 publications · 1.1K citations

    16

    h-index

1–5