Concepedia

Insertional Mutagenesis

Insertional Mutagenesis is a genome integration strategy in which the insertion of exogenous DNA sequences into a host genome disrupts or alters the function of endogenous genes, thereby generating heritable mutations that can be used to study gene function or drive phenotypic change.

1.6K

Publications

139.7K

Citations

7.4K

Authors

1.6K

Institutions

Publications per year

2017–2026

146

Parents

Publications

1.6K

Genome-Wide Insertional Mutagenesis of <i>Arabidopsis thaliana</i>

José M. Alonso, Anna N. Stepanova, Thomas J. Leisse et al. · Science · 2003 · 5.1K citations

, , +15

In vitro insertional mutagenesis with a selectable DNA fragment

Pierre Prentki, Henry Krisch · Gene · 1984 · 1.7K citations

, , +9

Induced Pluripotent Stem Cells Generated Without Viral Integration

Matthias Stadtfeld, Masaki Nagaya, Jochen Utikal et al. · Science · 2008 · 1.7K citations · Full text

, , +15

Insertional mutagenesis combined with acquired somatic mutations causes leukemogenesis following gene therapy of SCID-X1 patients

Steven J. Howe, Marc R. Mansour, Kerstin Schwarzwaelder et al. · Journal of Clinical Investigation · 2008 · 1.3K citations · Full text

, , +13

Simultaneous Identification of Bacterial Virulence Genes by Negative Selection

Michael Hensel, Jacqueline E. Shea, Colin Gleeson et al. · Science · 1995 · 1.2K citations

, , +17

1–5 of 1.6K

Authors

7.4K

  1. DJ
    David J. Adams

    Wellcome Sanger Institute, United Kingdom

    17 publications · 862 citations

    15

    h-index

  2. DA
    David A. Largaespada

    University of Minnesota, United States

    15 publications · 1.3K citations

    14

    h-index

  3. MS
    Manfred Schmidt

    National Center for Tumor Diseases, Germany

    16 publications · 3.5K citations

    14

    h-index

  4. NG
    Neal G. Copeland

    Cancer Research Center, United States

    16 publications · 1.6K citations

    13

    h-index

  5. CV
    Christof von Kalle

    National Center for Tumor Diseases, Germany

    14 publications · 3.4K citations

    13

    h-index

1–5 of 7.4K

Institutions

1.6K

  1. Harvard University

    Cambridge, United States

    36 h-index

    131 publications

    36.5K citations

  2. Howard Hughes Medical Institute

    Chevy Chase, United States

    35 h-index

    118 publications

    31.2K citations

  3. University of Minnesota

    Minneapolis, United States

    31 h-index

    221 publications

    19.6K citations

  4. National Cancer Institute

    Bethesda, United States

    29 h-index

    150 publications

    12.8K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    29 h-index

    114 publications

    12.1K citations

  6. National Institutes of Health

    Bethesda, United States

    27 h-index

    106 publications

    10.7K citations

  7. Center for Cancer Research

    Bethesda, United States

    24 h-index

    105 publications

    24.5K citations

  8. Johns Hopkins University

    Baltimore, United States

    22 h-index

    131 publications

    15.7K citations

1–8 of 1.6K

Venues

  1. Proceedings of the National Academy of Sciences

    PNAS · 93 publications · 15.7K citations

    67

    h-index

  2. Journal of Bacteriology

    JB · 118 publications · 9.7K citations

    58

    h-index

  3. Genetics

    46 publications · 5.6K citations

    36

    h-index

  4. Molecular Microbiology

    43 publications · 4.3K citations

    35

    h-index

  5. Infection and Immunity

    IAI · 43 publications · 3.5K citations

    34

    h-index

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