Concepedia

Synthesis, antiviral activity, and conformational studies of a P3 aza-peptide analog of a potent macrocyclic tripeptide HCV protease inhibitor

John T. Randolph, Xiaolin Zhang, Peggy Huang, Larry L. Klein, Kevin A. Kurtz, Alex K. Konstantinidis, Wenping He, Warren M. Kati, Dale J. Kempf

Bioorganic & Medicinal Chemistry Letters · 2008 · 27 citations · 9 references

DOI

Concepts

References

9

An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

Daniel Lamarre, Paul C. Anderson, Murray D. Bailey et al. · Nature · 2003 · 913 citations

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The burden of hepatitis C in the United States

Hepatology · 2002 · 299 citations · Full text

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Structure−Activity Study on a Novel Series of Macrocyclic Inhibitors of the Hepatitis C Virus NS3 Protease Leading to the Discovery of BILN 2061

Montse Llinàs‐Brunet, Murray D. Bailey, Gordon T. Bolger et al. · Journal of Medicinal Chemistry · 2004 · 186 citations

, , +17

Mutations Conferring Resistance to a Potent Hepatitis C Virus Serine Protease Inhibitor In Vitro

Liangjun Lu, Kent D. Stewart, John T. Randolph et al. · Antimicrobial Agents and Chemotherapy · 2004 · 164 citations · Full text

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Synthesis of BILN 2061, an HCV NS3 Protease Inhibitor with Proven Antiviral Effect in Humans

Anne‐Marie Faucher, Murray D. Bailey, Pierre L. Beaulieu et al. · Organic Letters · 2004 · 103 citations

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