An NS3 protease inhibitor with antiviral effects in humans infected with hepatitis C virus

Daniel Lamarre, Paul C. Anderson, Murray D. Bailey, +25

Nature

Antiviral EffectsHepatologyHepatitis C VirusViral HepatitisNs3 Protease Inhibitor +7

Cyclopropanation with Diazomethane and Bis(oxazoline)palladium(II) Complexes

Scott E. Denmark, Robert A. Stavenger, Anne‐Marie Faucher, +1

The Journal of Organic Chemistry

Inorganic ChemistryChemical EngineeringEngineeringAlkene MetathesisCoordination Complex +8

Herpes simplex virus helicase-primase inhibitors are active in animal models of human disease

James J. Crute, Christine A. Grygon, Karl D. Hargrave, +6

Nature Medicine

Molecular VirologyViral PersistencePathogenesisViral PathogenesisHuman Disease +5

Structure−Activity Study on a Novel Series of Macrocyclic Inhibitors of the Hepatitis C Virus NS3 Protease Leading to the Discovery of BILN 2061

Montse Llinàs‐Brunet, Murray D. Bailey, Gordon T. Bolger, +14

Journal of Medicinal Chemistry

Competitive Hexapeptide InhibitorsPharmacotherapyAntiviral DrugPharmaceutical ChemistryDrug Resistance +14

Discovery of BI 224436, a Noncatalytic Site Integrase Inhibitor (NCINI) of HIV-1

Lee D. Fader, Éric Malenfant, Mathieu Parisien, +32

ACS Medicinal Chemistry Letters

Hiv-1 IntegraseImmunologyMolecular BiologyPharmacotherapyBi 224436 +14

Preparation of Chiral Bisoxazolines: Observations on the Effect of Substituents

Scott E. Denmark, Noriyuki Nakajima, O. J.‐C. NICAISE, +2

The Journal of Organic Chemistry

Molecular SciencesChemical MeasurementChemical AnalysisSubstituentsscott E. DenmarkAltmetric Attention Score +11

Distinct Effects of Two HIV-1 Capsid Assembly Inhibitor Families That Bind the Same Site within the N-Terminal Domain of the Viral CA Protein

Christopher T. Lemke, Steve Titolo, Uta von Schwedler, +16

Journal of Virology

Discovery of Small-Molecule Inhibitors of the ATPase Activity of Human Papillomavirus E1 Helicase

Anne‐Marie Faucher, Peter W. White, Christian Brochu, +3

Journal of Medicinal Chemistry

Bioorganic ChemistryMolecular BiologySmall-molecule InhibitorsViral Structural ProteinChemical Biology +16

Discovery of a 1,5-dihydrobenzo[b][1,4]diazepine-2,4-dione series of inhibitors of HIV-1 capsid assembly

Lee D. Fader, Richard C. Bethell, Pierre Bonneau, +22

Bioorganic & Medicinal Chemistry Letters

Combinatorial ChemistryMedicinal ChemistryHeterocyclicBiochemistryNatural Sciences +6

Synthesis of BILN 2061, an HCV NS3 Protease Inhibitor with Proven Antiviral Effect in Humans

Anne‐Marie Faucher, Murray D. Bailey, Pierre L. Beaulieu, +11

Organic Letters

Medicinal ChemistryNs3 Protease InhibitorMedicineImmunologyAntiviral Drug Development +11