SIRT1 regulates the histone methyl-transferase SUV39H1 during heterochromatin formation

Transcriptional silencing and longevity protein Sir2 is an NAD-dependent histone deacetylase

Shin‐ichiro Imai, Christopher M. Armstrong, Matt Kaeberlein et al. · Nature · 2000 · 3.5K citations

Histone Modifications, Chromatin, Transcriptional Regulation +12

Regulation of chromatin structure by site-specific histone H3 methyltransferases

Stephen Rea, Frank Eisenhaber, Dónal O’Carroll et al. · Nature · 2000 · 2.8K citations

Histone Modifications, Chromatin, Transcriptional Regulation +12

Loss of the Suv39h Histone Methyltransferases Impairs Mammalian Heterochromatin and Genome Stability

Antoine H.F.M. Peters, Dónal O’Carroll, Harry Scherthan et al. · Cell · 2001 · 1.7K citations · Full text

Histone Modifications, Chromatin, Genome Stability +15

G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

Makoto Tachibana, Kenji Sugimoto, Masami Nozaki et al. · Genes & Development · 2002 · 1.2K citations · Full text

Developmental defects and p53 hyperacetylation in Sir2 homolog (SIRT1)-deficient mice

Hwei-Ling Cheng, Raúl Mostoslavsky, Shinichi Saito et al. · Proceedings of the National Academy of Sciences · 2003 · 1.1K citations · Full text

Sirt1 Function, Genetics, Apoptosis +19