Design, synthesis and structural exploration of novel fluorinated dabigatran derivatives as direct thrombin inhibitors

Dabigatran versus Warfarin in Patients with Atrial Fibrillation

Stuart J. Connolly, Michael D. Ezekowitz, Salim Yusuf et al. · New England Journal of Medicine · 2009 · 11.2K citations · Full text

Medicine, Cardiology, Pharmacotherapy +12

The Many Roles for Fluorine in Medicinal Chemistry

William K. Hagmann · Journal of Medicinal Chemistry · 2008 · 3.6K citations · Full text

Pharmacy, Medicinal Chemistry, Drug Design +5

Fluorination in Medicinal Chemistry: Methods, Strategies, and Recent Developments

Kenneth L. Kirk · Organic Process Research & Development · 2008 · 1.1K citations

Pharmacy, Chemistry, Medicinal Chemistry +10

Fluorine in medicinal chemistry: Recent therapeutic applications of fluorinated small molecules

Kenneth L. Kirk · Journal of Fluorine Chemistry · 2006 · 892 citations

Pharmacy, Chemistry, Medicinal Chemistry +13

The pharmacokinetics, pharmacodynamics and tolerability of dabigatran etexilate, a new oral direct thrombin inhibitor, in healthy male subjects

Joachim Stangier, Karin Rathgen, Hildegard Stähle et al. · British Journal of Clinical Pharmacology · 2007 · 884 citations · Full text

Medicine, Pharmacokinetics, Pharmacology +17