Fluorine in medicinal chemistry: Recent therapeutic applications of fluorinated small molecules

Structural Mechanism for Statin Inhibition of HMG-CoA Reductase

Eva S. Istvan, J. Deisenhofer · Science · 2001 · 1.6K citations

Life Sciences, Biochemistry, Molecular Biology +15

Fluorinated Pyrimidines, A New Class of Tumour-Inhibitory Compounds

Charles Heidelberger, P Danneberg, Dorothy Mooren et al. · Nature · 1957 · 1.6K citations

Medicine, Medicinal Chemistry, Oncology +11

A selective peroxisome proliferator-activated receptor δ agonist promotes reverse cholesterol transport

William R. Oliver, Jennifer L. Shenk, Mike R. Snaith et al. · Proceedings of the National Academy of Sciences · 2001 · 1K citations · Full text

Life Sciences, Medicinal Chemistry, Pharmacology +15

(2<i>R</i>)-4-Oxo-4-[3-(Trifluoromethyl)-5,6-dihydro[1,2,4]triazolo[4,3-<i>a</i>]pyrazin- 7(8<i>H</i>)-yl]-1-(2,4,5-trifluorophenyl)butan-2-amine:  A Potent, Orally Active Dipeptidyl Peptidase IV Inhibitor for the Treatment of Type 2 Diabetes

Dooseop Kim, Liping Wang, Maria Beconi et al. · Journal of Medicinal Chemistry · 2004 · 817 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +15

Molecular characterization of the melanin-concentrating-hormone receptor

Yumiko Saito, Hans‐Peter Nothacker, Zhiwei Wang et al. · Nature · 1999 · 545 citations

Life Sciences, Biochemistry, Molecular Biology +14