Concepedia

Celecoxib analogs possessing a N-(4-nitrooxybutyl)piperidin-4-yl or N-(4-nitrooxybutyl)-1,2,3,6-tetrahydropyridin-4-yl nitric oxide donor moiety: Synthesis, biological evaluation and nitric oxide release studies

Morshed Alam Chowdhury, Khaled R.A. Abdellatif, Ying Dong, Gang Yu, Zhangjian Huang, Moshfiqur Rahman, Dipankar Das, Carlos Velázquez, Mavanur R. Suresh, Edward E. Knaus

Bioorganic & Medicinal Chemistry Letters · 2010 · 57 citations · 16 references

DOIFull text

Open access

Concepts

References

16

Synthesis and Biological Evaluation of the 1,5-Diarylpyrazole Class of Cyclooxygenase-2 Inhibitors:  Identification of 4-[5-(4-Methylphenyl)-3- (trifluoromethyl)-1<i>H</i>-pyrazol-1-yl]benzenesulfonamide (SC-58635, Celecoxib)

Thomas D. Penning, John J. Talley, Stephen R. Bertenshaw et al. · Journal of Medicinal Chemistry · 1997 · 2K citations · Full text

, , +17

Syntheses, Calcium Channel Agonist−Antagonist Modulation Activities, and Nitric Oxide Release Studies of Nitrooxyalkyl 1,4-Dihydro-2,6-dimethyl-3-nitro-4-(2,1,3-benzoxadiazol-4-yl)pyridine-5-carboxylate Racemates, Enantiomers, and Diastereomers

Rudong Shan, Carlos Velázquez, Edward E. Knaus · Journal of Medicinal Chemistry · 2003 · 172 citations

, , +13

Esterase-Sensitive Nitric Oxide Donors of the Diazeniumdiolate Family:  In Vitro Antileukemic Activity

Joseph E. Saavedra, Paul J. Shami, Lai Yi Wang et al. · Journal of Medicinal Chemistry · 1999 · 131 citations

, , +14

Design, Synthesis, and Biological Evaluation of 6-Substituted-3-(4-methanesulfonylphenyl)-4-phenylpyran-2-ones:  A Novel Class of Diarylheterocyclic Selective Cyclooxygenase-2 Inhibitors

Praveen P. N. Rao, Huiying Li, Amgad G. Habeeb et al. · Journal of Medicinal Chemistry · 2003 · 110 citations · Full text

, , +13

Synthesis and Selective Cyclooxygenase-2 Inhibitory Activity of a Series of Novel, Nitric Oxide Donor-Containing Pyrazoles

Ramani R. Ranatunge, Michael E. Augustyniak, Upul K. Bandarage et al. · Journal of Medicinal Chemistry · 2004 · 76 citations · Full text

, , +12