Concepedia

Dual regulation of macrophage migration inhibitory factor (MIF) expression in hypoxia by CREB and HIF-1

John A. Baugh, Michael P. Gantier, Lili Li, Aileen Byrne, Avril Buckley, Seamas C. Donnelly

Biochemical and Biophysical Research Communications · 2006 · 138 citations · 58 references

DOI

Concepts

References

58

Hypoxia-inducible factor 1 is a basic-helix-loop-helix-PAS heterodimer regulated by cellular O2 tension.

G L Wang, Bing‐Hua Jiang, E A Rue et al. · Proceedings of the National Academy of Sciences · 1995 · 6.2K citations

, , +17

Cyclic AMP stimulates somatostatin gene transcription by phosphorylation of CREB at serine 133

Gustavo González, Marc Montminy · Cell · 1989 · 2.5K citations

, , +14

MIF is a pituitary-derived cytokine that potentiates lethal endotoxaemia

J. Bernhagen, Thierry Calandra, Robert A. Mitchell et al. · Nature · 1993 · 998 citations

, , +12

The macrophage is an important and previously unrecognized source of macrophage migration inhibitory factor.

Thierry Calandra, Jürgen Bernhagen, Robert A. Mitchell et al. · The Journal of Experimental Medicine · 1994 · 990 citations · Full text

, , +14

Protection from septic shock by neutralization of macrophage migration inhibitory factor

Thierry Calandra, Bernd Echtenacher, Didier Le Roy et al. · Nature Medicine · 2000 · 725 citations

, , +11