Concepedia

A phase I trial of the pharmacokinetics, toxicity, and activity of KNI-272, an inhibitor of HIV-1 protease, in patients with AIDS or symptomatic HIV infection

R.W. Humphrey, Kathleen M. Wyvill, Bach-Yen Nguyen, Laura E. Shay, David Köhler, Seth M. Steinberg, Takamasa Ueno, Tominaga Fukasawa, Makoto Shintani, Hideya Hayashi,

Antiviral Research · 1999 · 10 citations · 24 references

DOI

Concepts

References

24

In vivo emergence of HIV-1 variants resistant to multiple protease inhibitors

Jon H. Condra, William A. Schleif, O M Blahy et al. · Nature · 1995 · 979 citations

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Rational Design of Peptide-Based HIV Proteinase Inhibitors

Noel A. Roberts, Joseph A. Martin, Derek Kinchington et al. · Science · 1990 · 925 citations

, , +17

Ordered accumulation of mutations in HIV protease confers resistance to ritonavir

Akhteruzzaman Molla, Marina Korneyeva, Qing Gao et al. · Nature Medicine · 1996 · 768 citations

, , +14

A Short-Term Study of the Safety, Pharmacokinetics, and Efficacy of Ritonavir, an Inhibitor of HIV-1 Protease

Sven A. Danner, Andrew Carr, John M. Leonard et al. · New England Journal of Medicine · 1995 · 573 citations · Full text

, , +17

Design, Activity, and 2.8 Å Crystal Structure of a <i>C</i> <sub>2</sub> Symmetric Inhibitor Complexed to HIV-1 Protease

John W. Erickson, David J. Neidhart, John H. VanDrie et al. · Science · 1990 · 528 citations · Full text

, , +17