Makoto Shintani

JE-2147: A dipeptide protease inhibitor (PI) that potently inhibits multi-PI-resistant HIV-1

Kazuhisa Yoshimura, Ryohei Kato, Keisuke Yusa et al. · Proceedings of the National Academy of Sciences · 1999 · 108 citations

Effects of solvents on the production of epoxides by Nocardia corallina B-276

Keizo Furuhashi, Makoto Shintani, Motoyoshi Takagi · Applied Microbiology and Biotechnology · 1986 · 77 citations

Nocardia Corallina B-276, Biosynthesis, Bioorganic Chemistry +8

Rational design and synthesis of a novel class of active site-targeted HIV protease inhibitors containing a hydroxymethylcarbonyl isostere. Use of phenylnorstatine or allophenylnorstatine as a transition-state mimic.

Tsutomu Mimoto, Junya Imai, Shigeki Tanaka et al. · Chemical and Pharmaceutical Bulletin · 1991 · 75 citations · Full text

Medicinal Chemistry, Bioorganic Chemistry, Antiviral Compound +15

Structure−Activity Relationship of Small-Sized HIV Protease Inhibitors Containing Allophenylnorstatine

Tsutomu Mimoto, Ryohei Kato, Haruo Takaku et al. · Journal of Medicinal Chemistry · 1999 · 70 citations · Full text

Protease Inhibitors, Medicinal Chemistry, Bioorganic Chemistry +14

Structure-Activity Relationship of Orally Potent Tripeptide-Based HIV Protease Inhibitors Containing Hydroxymethylcarbonyl Isostere.

Tsutomu Mimoto, Naoko Hattori, Haruo Takaku et al. · Chemical and Pharmaceutical Bulletin · 2000 · 45 citations · Full text

Bioorganic Chemistry, Pharmacotherapy, Antiviral Drug +16