DNA Damage Response and Inflammatory Signaling Limit the MLL-ENL-Induced Leukemogenesis In Vivo

A biomarker that identifies senescent human cells in culture and in aging skin in vivo.

Goberdhan P. Dimri, X Lee, George Basile et al. · Proceedings of the National Academy of Sciences · 1995 · 7.3K citations · Full text

Replicative Senescence, Developmental Biology, Aging +14

DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis

Jiřina Bártková, Zuzana Hořejšı́, Karen Koed et al. · Nature · 2005 · 2.7K citations

Chromatin, Tumor Biology, Genome Instability +11

Persistent DNA damage signalling triggers senescence-associated inflammatory cytokine secretion

Françis Rodier, Jean‐Philippe Coppé, Christopher K. Patil et al. · Nature Cell Biology · 2009 · 2.1K citations · Full text

Inflammation, Dna Damage, Aging +8

Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions

Vassilis G. Gorgoulis, Leandros-Vassilios Vassiliou, Panagiotis Karakaidos et al. · Nature · 2005 · 2K citations

Dna Damage Checkpoint, Genome Instability, Dna Damage +11

Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints

Jiřina Bártková, Nousin Rezaei, Michalis Liontos et al. · Nature · 2006 · 1.9K citations

Oncogene-induced Senescence, Chromatin, Genome Instability +11