Concepedia

Raf Inhibitors Target Ras Spatiotemporal Dynamics

Kwang-Jin Cho, Rinshi S. Kasai, Jin-Hee Park, Sravanthi Chigurupati, Sonja J. Heidorn, Dharini van der Hoeven, Sarah J. Plowman, Akihiro Kusumi, Richard Marais, John F. Hancock

Current Biology · 2012 · 71 citations · 32 references

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32

BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

Scott M. Wilhelm, Christopher Carter, LiYa Tang et al. · Cancer Research · 2004 · 4K citations · Full text

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Inhibition of Mutated, Activated BRAF in Metastatic Melanoma

Keith T. Flaherty, Igor Puzanov, Kevin B. Kim et al. · New England Journal of Medicine · 2010 · 3.5K citations

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Modelling Spatial Patterns

B. D. Ripley · Journal of the Royal Statistical Society Series B (Statistical Methodology) · 1977 · 2.5K citations

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RAF inhibitors transactivate RAF dimers and ERK signalling in cells with wild-type BRAF

Poulikos I. Poulikakos, Chao Zhang, Gideon Bollag et al. · Nature · 2010 · 1.8K citations · Full text

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RAF inhibitors prime wild-type RAF to activate the MAPK pathway and enhance growth

Georgia Hatzivassiliou, Kyung Song, Ivana Yen et al. · Nature · 2010 · 1.6K citations

, , +15