Concepedia

Development of a highly selective, orally bioavailable and CNS penetrant M1 agonist derived from the MLPCN probe ML071

Evan P. Lebois, Gregory J. Digby, Douglas J. Sheffler, Bruce J. Melancon, James C. Tarr, Hyekyung P. Cho, Nicole Miller, Ryan D. Morrison, Thomas M. Bridges, Zixiu Xiang,

Bioorganic & Medicinal Chemistry Letters · 2011 · 37 citations · 25 references

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References

25

Effects of Xanomeline, a Selective Muscarinic Receptor Agonist, on Cognitive Function and Behavioral Symptoms in Alzheimer Disease

N. Bodick, Walter Offen, Allan I. Levey et al. · Archives of Neurology · 1997 · 685 citations

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Selective Muscarinic Receptor Agonist Xanomeline as a Novel Treatment Approach for Schizophrenia

Anantha Shekhar, William Z. Potter, Jeffrey Lightfoot et al. · American Journal of Psychiatry · 2008 · 559 citations

, , +17

M1 Receptors Play a Central Role in Modulating AD-like Pathology in Transgenic Mice

Antonella Caccamo, Salvatore Oddo, Lauren M. Billings et al. · Neuron · 2006 · 410 citations · Full text

, , +8

N-desmethylclozapine, an allosteric agonist at muscarinic 1 receptor, potentiates N-methyl- <scp>d</scp> -aspartate receptor activity

Cyrille Sur, Pierre Mallorga, Marion Wittmann et al. · Proceedings of the National Academy of Sciences · 2003 · 291 citations · Full text

, , +16

Selective activation of the M <sub>1</sub> muscarinic acetylcholine receptor achieved by allosteric potentiation

Lei Ma, Matthew A. Seager, Marion Wittmann et al. · Proceedings of the National Academy of Sciences · 2009 · 284 citations · Full text

, , +17