Redirected Antitumor Activity of Primary Human Lymphocytes Transduced With a Fully Human Anti-mesothelin Chimeric Receptor

Sensitive and viable identification of antigen-specific CD8+ T cells by a flow cytometric assay for degranulation

Michael R. Betts, Jason M. Brenchley, David A. Price et al. · Journal of Immunological Methods · 2003 · 1.6K citations

Life Sciences, Cell Biology, Immunology +14

Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity.

G. Gross, Tova Waks, Zelig Eshhar · Proceedings of the National Academy of Sciences · 1989 · 1.6K citations · Full text

Life Sciences, Immunology, Molecular Biology +17

A Phase I Study on Adoptive Immunotherapy Using Gene-Modified T Cells for Ovarian Cancer

Michael H. Kershaw, Jennifer A. Westwood, Linda L. Parker et al. · Clinical Cancer Research · 2006 · 1.2K citations · Full text

Medicine, Immunology, Oncology +17

Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo

Michael C. Milone, Jonathan D. Fish, Carmine Carpenito et al. · Molecular Therapy · 2009 · 1.2K citations · Full text

Life Sciences, Immunology, Oncology +17

T Cells Targeting Carcinoembryonic Antigen Can Mediate Regression of Metastatic Colorectal Cancer but Induce Severe Transient Colitis

Maria R. Parkhurst, James C. Yang, Russell C. Langan et al. · Molecular Therapy · 2010 · 1K citations · Full text

Life Sciences, Immunology, Oncology +17