A human memory T cell subset with stem cell–like properties

Luca Gattinoni, Enrico Lugli, Yun Ji, +14

Nature Medicine

Human CellMedicineMemoryStem Cell ResearchNeuroscience +6

Chimeric Receptors Containing CD137 Signal Transduction Domains Mediate Enhanced Survival of T Cells and Increased Antileukemic Efficacy In Vivo

Michael C. Milone, Jonathan D. Fish, Carmine Carpenito, +11

Molecular Therapy

Establishment of HIV-1 resistance in CD4+ T cells by genome editing using zinc-finger nucleases

Elena Pérez, Jianbin Wang, Jeffrey C. Miller, +20

Nature Biotechnology

Viral ReplicationHiv-1 ResistanceNatural SciencesHuman RetrovirusImmunology +10

Control of large, established tumor xenografts with genetically retargeted human T cells containing CD28 and CD137 domains

Carmine Carpenito, Michael C. Milone, Raffit Hassan, +11

Proceedings of the National Academy of Sciences

Expression of a Functional CCR2 Receptor Enhances Tumor Localization and Tumor Eradication by Retargeted Human T cells Expressing a Mesothelin-Specific Chimeric Antibody Receptor

Edmund K. Moon, Carmine Carpenito, Jing Sun, +7

Clinical Cancer Research

Multiple Injections of Electroporated Autologous T Cells Expressing a Chimeric Antigen Receptor Mediate Regression of Human Disseminated Tumor

Yangbing Zhao, Edmund K. Moon, Carmine Carpenito, +9

Cancer Research

Multiple InjectionsImmunologyImmunoeditingAntigen ProcessingImmunotherapeutics +19

The CDK4/6 Inhibitor Abemaciclib Induces a T Cell Inflamed Tumor Microenvironment and Enhances the Efficacy of PD-L1 Checkpoint Blockade

David Schaer, Richard P. Beckmann, Jack Dempsey, +19

Cell Reports

ICOS-based chimeric antigen receptors program bipolar TH17/TH1 cells

Sònia Guedan, Xi Chen, Aviv Madar, +9

Blood

Identification of Chimeric Antigen Receptors That Mediate Constitutive or Inducible Proliferation of T Cells

Matthew J. Frigault, Ji‐Hyun Lee, Maria C. Basil, +16

Cancer Immunology Research

Adaptive Immune SystemImmunologyImmune RegulationImmunodominanceImmunologic Mechanism +24

<i>In Vivo</i> Persistence, Tumor Localization, and Antitumor Activity of CAR-Engineered T Cells Is Enhanced by Costimulatory Signaling through CD137 (4-1BB)

De-Gang Song, Qunrui Ye, Carmine Carpenito, +7

Cancer Research