Concepedia

Transgene Immunogenicity

Transgene Immunogenicity is the propensity of a transgene-encoded protein to elicit an adaptive immune response against its expressed product following gene therapy, distinguished from other sources of immunogenicity by its origin in exogenously delivered genetic material rather than host antigens or vector components.

40

Publications

3.6K

Citations

293

Authors

105

Institutions

Publications per year

2017–2026

12

Parents

Publications

40

Murine Leukemia Induced by Retroviral Gene Marking

Zhixiong Li, J. Düllmann, Bernd Schiedlmeier et al. · Science · 2002 · 654 citations

, , +14

Immunogenicity in humans of a recombinant bacterial antigen delivered in a transgenic potato

Carol O. Tacket, Hugh S. Mason, Genevieve A. Losonsky et al. · Nature Medicine · 1998 · 587 citations

, , +14

An adenoviral vector deleted for all viral coding sequences results in enhanced safety and extended expression of a leptin transgene

Manal Morsy, Mingcheng Gu, Sherri L. Motzel et al. · Proceedings of the National Academy of Sciences · 1998 · 370 citations

, , +16

Modulation of tolerance to the transgene product in a nonhuman primate model of AAV-mediated gene transfer to liver

Federico Mingozzi, Nicole C. Hasbrouck, Etiena Basner‐Tschakarjan et al. · Blood · 2007 · 248 citations · Full text

, , +16

Immunogenicity of recombinant LT-B delivered orally to humans in transgenic corn

Carol O. Tacket, Marcela F. Pasetti, Robert Edelman et al. · Vaccine · 2004 · 197 citations

, , +9

1–5 of 40

Authors

293

  1. QS
    Qin Su

    University of Massachusetts Chan Medical School, United States

    2 publications · 415 citations

    2

    h-index

  2. VR
    Valder R. Arruda

    Children's Hospital of Philadelphia, United States

    2 publications · 296 citations

    2

    h-index

  3. JF
    J. Fraser Wright

    Children's Hospital of Philadelphia, United States

    2 publications · 296 citations

    2

    h-index

  4. CO
    Carol O. Tacket

    University of Maryland, Baltimore, United States

    2 publications · 784 citations

    2

    h-index

  5. JM
    John M. Howell

    The University of Western Australia, Australia

    1 publications · 105 citations

    1

    h-index

1–5 of 293

Institutions

105

  1. University of Pennsylvania

    Philadelphia, United States

    5 h-index

    18 publications

    2.7K citations

  2. University of Maryland, Baltimore

    Baltimore, United States

    2 h-index

    6 publications

    2.4K citations

  3. University of Massachusetts Chan Medical School

    Worcester, United States

    2 h-index

    17 publications

    759 citations

  4. Sorbonne Université

    Paris, France

    2 h-index

    9 publications

    471 citations

  5. Children's Hospital of Philadelphia

    Philadelphia, United States

    2 h-index

    15 publications

    2.7K citations

  6. Centre National de la Recherche Scientifique

    Paris, France

    2 h-index

    13 publications

    241 citations

  7. Hokkaido University

    Sapporo, Japan

    2 h-index

    10 publications

    270 citations

  8. Inserm

    Paris, France

    2 h-index

    17 publications

    647 citations

1–8 of 105

Venues

  1. Human Gene Therapy

    4 publications · 170 citations

    4

    h-index

  2. Molecular Therapy

    3 publications · 265 citations

    3

    h-index

  3. Gene Therapy

    3 publications · 157 citations

    3

    h-index

  4. 2

    h-index

  5. PubMed

    Repository · 2 publications · 78 citations

    2

    h-index

1–5