Zelig Eshhar

Specific activation and targeting of cytotoxic lymphocytes through chimeric single chains consisting of antibody-binding domains and the gamma or zeta subunits of the immunoglobulin and T-cell receptors.

Zelig Eshhar, Tova Waks, G. Gross et al. · Proceedings of the National Academy of Sciences · 1993 · 1.6K citations · Full text

Chimeric Genes, Immunology, Immunodominance +17

Expression of immunoglobulin-T-cell receptor chimeric molecules as functional receptors with antibody-type specificity.

G. Gross, Tova Waks, Zelig Eshhar · Proceedings of the National Academy of Sciences · 1989 · 1.5K citations · Full text

Adaptive Immune System, T-regulatory Cell, Immunology +16

A Phase I Study on Adoptive Immunotherapy Using Gene-Modified T Cells for Ovarian Cancer

Michael H. Kershaw, Jennifer A. Westwood, Linda L. Parker et al. · Clinical Cancer Research · 2006 · 1.2K citations · Full text

A Herceptin-Based Chimeric Antigen Receptor with Modified Signaling Domains Leads to Enhanced Survival of Transduced T Lymphocytes and Antitumor Activity

Yangbing Zhao, Qiong J. Wang, Shicheng Yang et al. · The Journal of Immunology · 2009 · 293 citations · Full text

In vivo antitumor activity of T cells redirected with chimeric antibody/T-cell receptor genes.

Patrick Hwu, James C. Yang, R Cowherd et al. · PubMed · 1995 · 275 citations

Immunology, Immunodominance, Antigen Processing +17