Insulin degrading enzyme is expressed in the human cerebrovascular endothelium and in cultured human cerebrovascular endothelial cells

Diabetes mellitus and the risk of dementia

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Medicine, Geriatric Medicine, Neurology +17

Insulin-degrading enzyme regulates the levels of insulin, amyloid β-protein, and the β-amyloid precursor protein intracellular domain <i>in vivo</i>

Wesley Farris, Stefan Mansourian, Yang Chang et al. · Proceedings of the National Academy of Sciences · 2003 · 1.5K citations · Full text

Life Sciences, Genetics, Neuroscience +15

Insulin-degrading Enzyme Regulates Extracellular Levels of Amyloid β-Protein by Degradation

Wei Qiao Qiu, Dominic M. Walsh, Zhen Ye et al. · Journal of Biological Chemistry · 1998 · 800 citations · Full text

Life Sciences, Biochemistry, Neuroscience +17

Enhanced Proteolysis of β-Amyloid in APP Transgenic Mice Prevents Plaque Formation, Secondary Pathology, and Premature Death

Malcolm A. Leissring, Wesley Farris, Alice Y. Chang et al. · Neuron · 2003 · 708 citations · Full text

Life Sciences, Biochemistry, Neuroscience +16

Immunolocalization of von Willebrand protein in Weibel-Palade bodies of human endothelial cells

Denisa D. Wagner · The Journal of Cell Biology · 1982 · 708 citations · Full text

Medicine, Cell Biology, Pathology +9