Concepedia

Dietary Inulin Alleviates Hepatic Steatosis and Xenobiotics-Induced Liver Injury in Rats Fed a High-Fat and High-Sucrose Diet: Association with the Suppression of Hepatic Cytochrome P450 and Hepatocyte Nuclear Factor 4α Expression

Junko Sugatani, Tadashi Wada, Makoto Osabe, Kasumi Yamakawa, Kouichi Yoshinari, Masao Miwa

Drug Metabolism and Disposition · 2006 · 68 citations · 39 references

DOI

Concepts

References

39

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

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Expanding the natural history of nonalcoholic steatohepatitis: From cryptogenic cirrhosis to hepatocellular carcinoma

Elisabetta Bugianesi, Nicola Leone, Ester Vanni et al. · Gastroenterology · 2002 · 1.4K citations · Full text

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CYP2E1 and CYP4A as microsomal catalysts of lipid peroxides in murine nonalcoholic steatohepatitis

Isabelle Leclercq, Geoffrey C. Farrell, Jaqueline Field et al. · Journal of Clinical Investigation · 2000 · 772 citations · Full text

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The Nuclear Orphan Receptor CAR-Retinoid X Receptor Heterodimer Activates the Phenobarbital-Responsive Enhancer Module of the <i>CYP2B</i> Gene

Paavo Honkakoski, Igor N. Zelko, Tatsuya Sueyoshi et al. · Molecular and Cellular Biology · 1998 · 705 citations

, , +17

Hepatic cytochrome P450 2E1 is increased in patients with nonalcoholic steatohepatitis

Martin Weltman, Geoffrey C. Farrell, Pauline de la Μ. Hall et al. · Hepatology · 1998 · 612 citations · Full text

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