Makoto Osabe

Dephosphorylation of Threonine 38 Is Required for Nuclear Translocation and Activation of Human Xenobiotic Receptor CAR (NR1I3)

Shingo Mutoh, Makoto Osabe, Kaoru Inoue et al. · Journal of Biological Chemistry · 2009 · 135 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Expression of Hepatic UDP-Glucuronosyltransferase 1A1 and 1A6 Correlated with Increased Expression of the Nuclear Constitutive Androstane Receptor and Peroxisome Proliferator-Activated Receptor α in Male Rats Fed a High-Fat and High-Sucrose Diet

Makoto Osabe, Junko Sugatani, Tomoaki Fukuyama et al. · Drug Metabolism and Disposition · 2007 · 90 citations

Life Sciences, Biochemistry, Nutritional Sciences +17

Dietary Inulin Alleviates Hepatic Steatosis and Xenobiotics-Induced Liver Injury in Rats Fed a High-Fat and High-Sucrose Diet: Association with the Suppression of Hepatic Cytochrome P450 and Hepatocyte Nuclear Factor 4α Expression

Junko Sugatani, Tadashi Wada, Makoto Osabe et al. · Drug Metabolism and Disposition · 2006 · 68 citations

Life Sciences, Nutrition, Nutritional Sciences +17

Active ERK1/2 Protein Interacts with the Phosphorylated Nuclear Constitutive Active/Androstane Receptor (CAR; NR1I3), Repressing Dephosphorylation and Sequestering CAR in the Cytoplasm

Makoto Osabe, Masahiko Negishi · Journal of Biological Chemistry · 2011 · 58 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +16

Transcriptional regulation of human UGT1A1 gene expression through distal and proximal promoter motifs: implication of defects in the UGT1A1 gene promoter

Junko Sugatani, Kousuke Mizushima, Makoto Osabe et al. · Naunyn-Schmiedeberg s Archives of Pharmacology · 2008 · 57 citations

Life Sciences, Genetics, Molecular Biology +17