Rate-Limiting Steps in Hepatic Drug Clearance: Comparison of Hepatocellular Uptake and Metabolism with Microsomal Metabolism of Saquinavir, Nelfinavir, and Ritonavir

The drug transporter P-glycoprotein limits oral absorption and brain entry of HIV-1 protease inhibitors.

Richard B. Kim, Martin F. Fromm, Christoph Wandel et al. · Journal of Clinical Investigation · 1998 · 1.1K citations · Full text

Pharmacy, Pharmacokinetics, Pharmacology +17

Fruit juices inhibit organic anion transporting polypeptide–mediated drug uptake to decrease the oral availability of fexofenadine

George K. Dresser, David G. Bailey, Brenda F. Leake et al. · Clinical Pharmacology & Therapeutics · 2002 · 606 citations

Pharmacy, Pharmacokinetics, Pharmacology +17

Cytochrome P450-mediated metabolism of the HIV-1 protease inhibitor ritonavir (ABT-538) in human liver microsomes.

Gondi Kumar, A. David Rodrigues, Alex Buko et al. · Journal of Pharmacology and Experimental Therapeutics · 1996 · 352 citations

Medicine, Pharmacokinetics, Pharmacology +17

Inhibition of Transporter-Mediated Hepatic Uptake as a Mechanism for Drug-Drug Interaction between Cerivastatin and Cyclosporin A

Yoshihisa Shitara, Tomoo Itoh, Hitoshi Sato et al. · Journal of Pharmacology and Experimental Therapeutics · 2003 · 340 citations · Full text

Medicine, Biochemistry, Pharmacology +17

Human Organic Anion Transporting Polypeptide-C (SLC21A6) Is a Major Determinant of Rifampin-Mediated Pregnane X Receptor Activation

Rommel G. Tirona, Brenda F. Leake, Allan W. Wolkoff et al. · Journal of Pharmacology and Experimental Therapeutics · 2003 · 326 citations

Medicine, Cell Biology, Pharmacology +14