Plant Foods for Human Nutrition · 2008 · 68 citations · 6 references
PharmacyPharmacologyToxicologyFood ToxicologyHepatotoxicologyNutritional ToxicologyChemical-induced HepatotoxicityHepatic ImpairmentHepatic NecrosisHepatic ToxicityHepatotoxicity MechanismsLiver DiseaseAspartate Aminotransferase ElevationCarbon Tetrachloride HepatotoxicityCarbon Tetrachloride NeurotoxicityCarbon Tetrachloride ToxicityFruit Juice ConsumptionHepatotoxic MechanismsSerum Alanine AminotransferaseSerum Aspartate Aminotransferase
This study evaluated the protective effects of Noni fruit juice on acute liver injury induced by carbon tetrachloride (CCl(4)) in female Sprague-Dawley (SD) rats. Liver damage (micro-centrilobular necrosis) was observed in animals pretreated with 20% placebo (drinking water) + CCl(4). However, pretreatment with 20% Noni juice in drinking water + CCl(4) resulted in markedly decreased hepatotoxic lesions. Furthermore, serum alanine aminotransferase and aspartate aminotransferase levels were significantly lower in the Noni group than the placebo group. In a correlative time-dependent study, one dose of CCl(4) (0.25 mL/kg in corn oil, p.o.) in female SD rats, pretreated with 10% placebo for 12 days, caused sequential progressive hepatotoxic lesions over a 24 h period, while a protective effect from 10% Noni juice pretreatment was observed. These results suggest that Noni juice is effective in protecting the liver from extrinsic toxin exposure.
6