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Loss of Epigenetic Modification Driven by the Foxp3 Transcription Factor Leads to Regulatory T Cell Insufficiency

Matthew L. Bettini, Fan Pan, Maria Bettini, David Finkelstein, Jerold E. Rehg, Stefan Floess, Bryan D. Bell, Steven F. Ziegler, Jochen Huehn, Drew M. Pardoll,

Immunity · 2012 · 164 citations · 38 references

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38

Regulatory T Cell Lineage Specification by the Forkhead Transcription Factor Foxp3

Jason D. Fontenot, Jeffrey P. Rasmussen, Luke M. Williams et al. · Immunity · 2005 · 2.2K citations · Full text

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Regulatory T cells prevent catastrophic autoimmunity throughout the lifespan of mice

Jeong Kim, Jeffrey P. Rasmussen, Alexander Y. Rudensky · Nature Immunology · 2006 · 1.8K citations

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Instability of the transcription factor Foxp3 leads to the generation of pathogenic memory T cells in vivo

Xuyu Zhou, Samantha L. Bailey-Bucktrout, Lukas T. Jeker et al. · Nature Immunology · 2009 · 1.3K citations · Full text

, , +14

Epigenetic Control of the foxp3 Locus in Regulatory T Cells

Stefan Floess, Jennifer Freyer, Christiane Siewert et al. · PLoS Biology · 2007 · 1.2K citations · Full text

, , +17

The transcription factor T-bet controls regulatory T cell homeostasis and function during type 1 inflammation

Meghan A. Koch, Glady’s Tucker-Heard, Nikole Perdue et al. · Nature Immunology · 2009 · 1.2K citations · Full text

, , +16