Solution-phase and solid-phase synthesis of novel transition state inhibitors of coagulation enzymes incorporating a piperidinyl moiety

Enzyme flexibility, solvent and ‘weak’ interactions characterize thrombin–ligand interactions: implications for drug design

Richard A. Engh, Hans Brandstetter, Gudrun Sucher et al. · Structure · 1996 · 97 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +17

Small-molecule direct thrombin inhibitors

Michael R. Wiley, Matthew J. Fisher · Expert Opinion on Therapeutic Patents · 1997 · 83 citations

Pharmacy, Biochemistry, Medicinal Chemistry +16

Potent Noncovalent Thrombin Inhibitors That Utilize the Unique Amino Acid <scp>d</scp>-Dicyclohexylalanine in the P3 Position. Implications on Oral Bioavailability and Antithrombotic Efficacy

Thomas J. Tucker, William C. Lumma, Sidney D. Lewis et al. · Journal of Medicinal Chemistry · 1997 · 58 citations · Full text

Pharmacy, Medicinal Chemistry, Pharmacology +12

Synthesis, evaluation, and crystallographic analysis of L-371,912: A potent and selective active-site thrombin inhibitor

Terry A. Lyle, Zhongguo Chen, Sandra D. Appleby et al. · Bioorganic & Medicinal Chemistry Letters · 1997 · 39 citations

Medicine, Medicinal Chemistry, Pharmacology +14

Synthesis of β-(4-Pyridyl)-DL-alanine and of β-(4-Pyridyl-1-oxide)-DL-, D-, and L-alanine¹

Robert L. Bixler, Carl Niemann · The Journal of Organic Chemistry · 1958 · 33 citations

Natural Sciences, Biochemistry, Chemistry +5