Edwin de Zwart

Acalabrutinib (ACP-196): A Covalent Bruton Tyrosine Kinase Inhibitor with a Differentiated Selectivity and In Vivo Potency Profile

Tjeerd Barf, Todd Covey, Raquel Izumi et al. · Journal of Pharmacology and Experimental Therapeutics · 2017 · 357 citations · Full text

Abstract 2596: ACP-196: a novel covalent Bruton's tyrosine kinase (Btk) inhibitor with improved selectivity and in vivo target coverage in chronic lymphocytic leukemia (CLL) patients

Todd Covey, Tjeerd Barf, Michael Gulrajani et al. · Cancer Research · 2015 · 44 citations

Abstract 2596, Tyrosine Kinase, Immunology +22

Discovery of selective and orally available spiro-3-piperidyl ATP-competitive MK2 inhibitors

Allard Kaptein, Arthur Oubrie, Edwin de Zwart et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 19 citations · Full text

Medicinal Chemistry, Biochemistry, Medicine +9

Solution-phase and solid-phase synthesis of novel transition state inhibitors of coagulation enzymes incorporating a piperidinyl moiety

Anton E.P. Adang, Co A.M. Peters, Siene Gerritsma et al. · Bioorganic & Medicinal Chemistry Letters · 1999 · 16 citations · Full text

Medicinal Chemistry, Solid-phase Synthesis, Biochemistry +8

Novel ATP competitive MK2 inhibitors with potent biochemical and cell-based activity throughout the series

Arthur Oubrie, Allard Kaptein, Edwin de Zwart et al. · Bioorganic & Medicinal Chemistry Letters · 2011 · 14 citations · Full text

Cell-based Activity, Novel Therapy, Biochemistry +8