An important role of phospholipase Cγ1 in pre‐B‐cell development and allelic exclusion

RAG-2-deficient mice lack mature lymphocytes owing to inability to initiate V(D)J rearrangement

Yoichi Shinkai · Cell · 1992 · 2.6K citations

Life Sciences, Genetics, Immunology +14

A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin μ chain gene

Daisuke Kitamura, Jürgen Roes, Ralf Kühn et al. · Nature · 1991 · 1.8K citations

Life Sciences, Genetics, Immunology +12

Early lymphocyte expansion is severely impaired in interleukin 7 receptor-deficient mice.

Jacques J. Peschon, Philip Morrissey, Kenneth H. Grabstein et al. · The Journal of Experimental Medicine · 1994 · 1.6K citations · Full text

Life Sciences, Genetics, Immunology +17

Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice

Christopher C. Goodnow, J. Crosbie, Stephen Adelstein et al. · Nature · 1988 · 1.6K citations

Life Sciences, Genetics, Immunology +16

LAT

Joanne Sloan‐Lancaster, J. Kitchen, Ronald P. Trible et al. · Cell · 1998 · 1.3K citations · Full text