Impaired autophagy response in human hepatocellular carcinoma

A lysosome-to-nucleus signalling mechanism senses and regulates the lysosome via mTOR and TFEB

Carmine Settembre, Roberto Zoncu, Diego L. Medina et al. · The EMBO Journal · 2012 · 1.9K citations · Full text

Chromatin, Signal Transduction, Cell Signaling +10

An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1

Carson C. Thoreen, Seong A. Kang, Jae Won Chang et al. · Journal of Biological Chemistry · 2009 · 1.8K citations · Full text

Autophagy-deficient mice develop multiple liver tumors

Akito Takamura, Masaaki Komatsu, Taichi Hara et al. · Genes & Development · 2011 · 1.3K citations · Full text

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2

Morris E. Feldman, Beth Apsel, Aino Uotila et al. · PLoS Biology · 2009 · 1.1K citations · Full text

Drug Target, Mrna Translation, Molecular Biology +24

Glypican-3: a novel serum and histochemical marker for hepatocellular carcinoma

Mariana Capurro, Ian R. Wanless, Morris Sherman et al. · Gastroenterology · 2003 · 893 citations

Hepatology, Novel Serum, Histopathology +8