Stanniocalcin 2 is associated with ectopic calcification in α-klotho mutant mice and inhibits hyperphosphatemia-induced calcification in aortic vascular smooth muscle cells

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa et al. · Nature · 1997 · 3.8K citations

Life Sciences, Genetics, Molecular Genetics +12

Klotho converts canonical FGF receptor into a specific receptor for FGF23

Itaru Urakawa, Yuji Yamazaki, Takashi Shimada et al. · Nature · 2006 · 1.8K citations

Life Sciences, Genetics, Molecular Biology +10

Phosphate Regulation of Vascular Smooth Muscle Cell Calcification

Shuichi Jono, Marc D. McKee, Charles E. Murry et al. · Circulation Research · 2000 · 1.4K citations

Medicine, Biochemistry, Physiology +15

Targeted ablation of Fgf23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism

Takashi Shimada, Makoto Kakitani, Y. Yamazaki et al. · Journal of Clinical Investigation · 2004 · 1.4K citations · Full text

Medicine, Endocrinology, Nephrology +17

Regulation of Fibroblast Growth Factor-23 Signaling by Klotho

Hiroshi Kurosu, Yasushi Ogawa, Masayoshi Miyoshi et al. · Journal of Biological Chemistry · 2006 · 1.4K citations · Full text

Life Sciences, Genetics, Molecular Biology +16