Concepedia

Identification of a Novel Allosteric Binding Site in the CXCR2 Chemokine Receptor

Petra de Kruijf, Herman D. Lim, Luc Roumen, Véronique A. Renjaän, Jiuqiao Zhao, Maria L. Webb, Douglas S. Auld, Jac C.H.M. Wijkmans, Guido J.R. Zaman, Martine J. Smit,

Molecular Pharmacology · 2011 · 29 citations · 32 references

DOI

Concepts

References

32

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

Yung-Chi Cheng, William H. Prusoff · Biochemical Pharmacology · 1973 · 12.9K citations

, , +14

High-Resolution Crystal Structure of an Engineered Human β <sub>2</sub> -Adrenergic G Protein–Coupled Receptor

Vadim Cherezov, Daniel M. Rosenbaum, Michael A. Hanson et al. · Science · 2007 · 3.3K citations · Full text

, , +17

Improved protein–ligand docking using GOLD

Marcel L. Verdonk, Jason C. Cole, Michael J. Hartshorn et al. · Proteins Structure Function and Bioinformatics · 2003 · 3K citations · Full text

, , +17

Structures of the CXCR4 Chemokine GPCR with Small-Molecule and Cyclic Peptide Antagonists

Beili Wu, Ellen Y. T. Chien, Clifford D. Mol et al. · Science · 2010 · 1.8K citations

, , +17

Crystal structure of the ligand-free G-protein-coupled receptor opsin

Jung Hee Park, Patrick Scheerer, Klaus Peter Hofmann et al. · Nature · 2008 · 901 citations · Full text

, , +14