Concepedia

Conditionally immortalized mouse hepatocytes for use in liver gene therapy

Katrina J. Allen, Rosario Reyes, Kirsten Demmler, Julian F. B. Mercer, Robert Williamson, Robert H. Whitehead

Journal of Gastroenterology and Hepatology · 2000 · 24 citations · 22 references

DOI

Abstract

Immortohepatocytes can survive in vivo after transfer to liver, and will be useful as a model for hepatic gene therapy.

References

22

Experimental pathology of the liver

Gm. Higgins · Medical Entomology and Zoology · 1931 · 3.1K citations

, , +10

Treatment of the Crigler–Najjar Syndrome Type I with Hepatocyte Transplantation

Ira J. Fox, Jayanta Roy Chowdhury, Stuart S. Kaufman et al. · New England Journal of Medicine · 1998 · 1K citations · Full text

, , +13

Direct derivation of conditionally immortal cell lines from an H-2Kb-tsA58 transgenic mouse.

Parmjit Jat, Mark Noble, Paris Ataliotis et al. · Proceedings of the National Academy of Sciences · 1991 · 745 citations · Full text

, , +21

Serial transplantation reveals the stem-cell-like regenerative potential of adult mouse hepatocytes.

Ken Overturf, Muhsen Al-Dhalimy, C N Ou et al. · PubMed · 1997 · 600 citations

Successful ex vivo gene therapy directed to liver in a patient with familial hypercholesterolaemia

Mariann Grossman, Steven E. Raper, Karen Kozarsky et al. · Nature Genetics · 1994 · 565 citations

, , +13